Lorenzo's Oil (1992)

This is the film where Miller's medical training matters most. It tells the true story of Augusto and Michaela Odone, played by Nick Nolte and Susan Sarandon, who taught themselves the science of their son Lorenzo's rare disease, adrenoleukodystrophy, when doctors had little to offer. Miller treats lab work and library research with the urgency of a chase, and Sarandon's ferocious performance earned a Best Actress nomination, alongside a screenplay nomination for Miller and Nick Enright. It is harrowing and demanding, so save it for a night when you want to be moved rather than thrilled.