Grumpy Cat

Her real name was Tardar Sauce, and her permanent scowl came from feline dwarfism and an underbite, not a bad mood. Photos of that face hit Reddit in 2012, and within months she was the default reaction image for every disappointment online. Grumpy Cat matters because she showed how far a meme could travel offline. Her owner, Tabatha Bundesen, built a company around her, she appeared in Honey Nut Cheerios commercials, and Lifetime made a 2014 holiday movie, "Grumpy Cat's Worst Christmas Ever," with Aubrey Plaza as her voice. She died on May 14, 2019, at age 7, from complications of a urinary tract infection. Her face is still the shorthand for "no."