Fringe (2008)

Lost co-creator J.J. Abrams launched this with Alex Kurtzman and Roberto Orci while Lost was still on air, and it scratches the mythology itch with far less waiting. Early episodes are weird-science cases for an FBI agent, a brilliant, unstable scientist and his son, but each one feeds a much bigger story about why these events are happening, and it is a story that gets explained. Push through the case-of-the-week stretch of the first season; it turns into one of the most emotionally rich sci-fi series of its era. All five seasons, finished on Fox in 2013, reach a proper ending.