The Amazing Spider-Man #1 (March 1963)

Spider-Man's own title opens with a cover by Jack Kirby and Steve Ditko that leans on Marvel's bestsellers: the Fantastic Four crowd in as guest stars while Spidey is trapped inside a glass capsule. The banner at the bottom promises the Chameleon, the first villain he faces in his own series, and this issue also introduces J. Jonah Jameson.