Skins (2007)

Bristol sixth-formers behaving very badly, written by a team whose average age was 21 and recast every two years, so each generation of the gang gets its own story. The first two series, with Tony, Sid and Cassie, are the ones most people remember, and their parties and soundtrack defined what British teenagers thought E4 was for. Expect drugs, sex and real grief, with no effort to make any of it wholesome.