It's Garry Shandling's Show (1986)

The sitcom that knows it's a sitcom. Garry Shandling plays himself, a neurotic comedian fully aware he's on television, and he spends about as much time chatting with the studio audience as with his cast, who sometimes get pulled into the storyline too. Even the theme song is a song about being the theme song. It aired on Showtime from 1986 to 1990, years before meta comedy was fashionable, and it still feels ahead of its time. Seek it out if you like your fourth-wall breaks playful rather than conspiratorial.