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Leroy Hood
Born
Leroy Hood's laboratory at Caltech, with Lloyd Smith, Michael Hunkapiller and others, built the automated fluorescent DNA sequencer described in 1986, which tagged each DNA letter with a different coloured dye so a machine could read it. His group also built automated protein sequencers and synthesisers. Automated sequencing made the Human Genome Project feasible.
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Jennifer Doudna
Born
Jennifer Doudna and Emmanuelle Charpentier, with Martin Jinek and colleagues, showed in 2012 that the bacterial CRISPR-Cas9 system could be programmed to cut DNA at a chosen place. Within months other groups, including Feng Zhang's, used it to edit genes in human and mouse cells. Gene editing became a standard laboratory tool, and the two women shared the 2020 Nobel prize in chemistry.
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