Slay the Spire (2019)

The original game's deck and relic engine must be assembled afresh on each climb. Early score-based unlocks expand the card and relic pools, while victories open harder Ascensions and access to the later act. Your previous run also affects the choice of starting blessing, so it is not an identical blank slate every time. What you cannot do is buy a permanent damage level for the Ironclad. Choose it for learning which card solves this run's problem, with a complete, established ruleset beside the sequel.